Product Name :
20-COOH-LTB4 (CAS 80434-82-8)
Synonym :
Application :
20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways
CAS:
80434-82-8
Purity:
>97%
Molecular Weight:
366.5
Formula :
C20H30O6
Physical state:
Liquid
solubility :
Soluble in water, ethanol, DMF, DMSO, and PBS pH 7.2.
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
C(CCC(=O)O)C/C=C\\C[C@H](/C=C/C=C/C=C\\[C@H](CCCC(=O)O)O)O
References:
:Defective metabolism of leukotriene B4 in the Sjögren-Larsson syndrome.1258874-29-1 site | Willemsen, MA., et al. 2001. J Neurol Sci. 183: 61-7. PMID: 11166796Prostaglandins and leukotrienes: advances in eicosanoid biology. | Funk, CD. 2001. Science. 294: 1871-5. PMID: 11729303Cytochrome P-450-dependent omega-oxidation of leukotriene B4 in rodent and human epidermis. | Mukhtar, H., et al. 1989. J Invest Dermatol. 93: 231-5. PMID: 2474030Purification and characterization of 20-hydroxy-leukotriene B4 dehydrogenase in human neutrophils. | Gotoh, Y., et al. 1989. Eur J Biochem. 179: 315-21. PMID: 2537206Studies on the uptake, binding and metabolism of leukotriene B4 by human neutrophils.Formula of 1547960-36-0 | Brom, J.PMID:33507266 and König, W. 1989. Immunology. 68: 479-85. PMID: 2558070Leukotriene B Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the omega -Oxidation of Leukotriene B In Vitro and In Cellulo. | Archambault, AS., et al. 2017. PLoS One. 12: e0169804. PMID: 28068410Activation of neutrophil chemotaxis by leukotriene B4 and 5-hydroxyeicosatetraenoic acid in chronic inflammatory bowel disease. | Nielsen, OH. and Elmgreen, J. 1987. Scand J Clin Lab Invest. 47: 605-11. PMID: 2823370The identification and formation of 20-aldehyde leukotriene B4. | Soberman, RJ., et al. 1988. J Biol Chem. 263: 7996-8002. PMID: 2836406Modulation of leukotriene release from human polymorphonuclear leucocytes by PMA and arachidonic acid. | Raulf, M. and König, W. 1988. Immunology. 64: 51-9. PMID: 2838420NAD+-dependent conversion of 20-OH-LTB4 to 20-COOH-LTB4 by a cell-free system of human polymorphonuclear leukocytes. | Sumimoto, H., et al. 1985. Biochem Biophys Res Commun. 132: 864-70. PMID: 3000366Metabolism of leukotriene B4 in isolated rat hepatocytes. Identification of a novel 18-carboxy-19,20-dinor leukotriene B4 metabolite. | Harper, TW., et al. 1986. J Biol Chem. 261: 5414-8. PMID: 3007501Abnormal metabolism of arachidonic acid in chronic inflammatory bowel disease: enhanced release of leucotriene B4 from activated neutrophils. | Nielsen, OH., et al. 1987. Gut. 28: 181-5. PMID: 3030903Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. | Shak, S. and Goldstein, IM. 1984. J Biol Chem. 259: 10181-7. PMID: 6088485Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes. | Powell, WS. 1984. J Biol Chem. 259: 3082-9. PMID: 6321494