Product Name :
TCF-1 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
TCF7 antibody TCF1 antibody Transcription factor 7 antibody TCF-7 antibody T-cell-specific transcription factor 1 antibody T-cell factor 1 antibody TCF-1 antibody
Function :
alternative products:2 series of isoforms, L and S, are produced by use of alternative promoter usage. Additional isoforms seem to exist,Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5′-WWCAAAG-3′) found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. induction:By TCF7L2 and CTNNB1. sequence caution:Wrong choice of frame. Belongs to the TCF/LEF family. Contains 1 HMG box DNA-binding domain. subunit:Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with AES, TLE1, TLE2, TLE3 and TLE4. tissue specificity:Predominantly in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
The antiserum was produced against synthesized peptide derived from human TCF7.Methyl 5-bromo-2,4-dimethylbenzoate Purity AA range:10-59
Species reactivity:
Human, Mouse
Verify application:
WB, IHC-P
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.330645-87-9 Price Aliquot store at -20℃ or -80℃.PMID:33555018 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
42 kDa
Positive control :
Liver,Skin,T-cell,T-cell lymphoma,Thymus,