Product Name :
2′,3′-Dideoxycytidine (CAS 7481-89-2)
Synonym :
ddC
Application :
2′,3′-Dideoxycytidine is an antiviral pyrimidine nucleoside analogue effective against HIV replication
CAS:
7481-89-2
Purity:
≥98%
Molecular Weight:
211.22
Formula :
C9H13N3O3
Physical state:
Solid
solubility :
Soluble in water (76.4 mg/ml at 25° C), DMSO (42 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Shipping Condition :
Store at -20° C
Melting point:
217-218° C (lit.)
SMILES:
C1C[C@@H](O[C@@H]1CO)N2C=CC(=NC2=O)N
References:
:Theoretical mechanistic basis of the toxic effects and efficacy of dideoxycytidine in HIV:AIDS. | Akintonwa, DA. 2001. Med Hypotheses. 57: 249-51. PMID: 11461183The molecular basis of inhibition and toxicity of modified cytosine analogues targetting HIV-1 reverse transcriptase. | Anderson, KS. 2001. Antivir Chem Chemother. 12 Suppl 1: 13-7. PMID: 11594679Pharmacodynamics of 2′,3′-dideoxycytidine: an inhibitor of human immunodeficiency virus.Fmoc-D-β-Homophenylalanine In stock | Broder, S. 1990. Am J Med. 88: 2S-7S. PMID: 1692446Zidovudine and other reverse transcriptase inhibitors in the management of human immunodeficiency virus-related disease. | Matthews, SJ., et al. 1991. Pharmacotherapy. 11: 419-48; discussion 448-9. PMID: 1722897Treatment of AIDS with combinations of antiretroviral agents. | Merigan, TC. 1991. Am J Med. 90: 8S-17S. PMID: 1850192Initial clinical experience with dideoxynucleosides as single agents and in combination therapy. | Yarchoan, R., et al. 1990. Ann N Y Acad Sci. 616: 328-43. PMID: 2078027Salvage therapy for zidovudine-intolerant HIV-infected patients with alternating and intermittent regimens of zidovudine and dideoxycytidine. | Bozzette, SA. and Richman, DD. 1990. Am J Med. 88: 24S-26S. PMID: 2159706Dideoxycytidine: current clinical experience and future prospects. A summary. | Broder, S. and Yarchoan, R. 1990. Am J Med. 88: 31S-33S. PMID: 2159708The antiviral activity of dideoxycytidine.Bis(cyclooctadiene)dichlorodirhodium Chemscene | Jeffries, DJ.PMID:33452210 1989. J Antimicrob Chemother. 23 Suppl A: 29-34. PMID: 25411262′,3′-Dideoxycytidine Protects Dopaminergic Neurons in a Mouse Model of Parkinson′s Disease. | Niu, J., et al. 2017. Neurochem Res. 42: 2996-3004. PMID: 286312312′,3′-Dideoxycytidine, a DNA Polymerase- beta Inhibitor, Reverses Memory Deficits in a Mouse Model of Alzheimer′s Disease. | Meng, L., et al. 2019. J Alzheimers Dis. 67: 515-525. PMID: 30584144Zalcitabine. An update of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of HIV infection. | Adkins, JC., et al. 1997. Drugs. 53: 1054-80. PMID: 91795312′,3′-Dideoxycytidine cytotoxicity in human macrophages. | Antonelli, A., et al. 1997. Biochim Biophys Acta. 1358: 39-45. PMID: 9296519